Micro-Scale R&D Granulation system TCT-100g & FBDG-100g
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The Micro-Scale R&D Granulation System consists of a 100 g High-Shear Mixer integrated with a 100 g Fluid-Bed Dryer Granulator, manufactured by T&T MACHINERY. This system is crucial for pharmaceutical formulation research and process optimization before scaling up to full-scale production lines.
🔧 1. System Structure — Micro-Scale R&D Granulation system TCT-100g & FBDG-100g
1. High-Shear Mixer Granulator – 100 g
Working capacity: approx. 100 g — ideal for formulation development and new product trials.
Main components:
Main impeller: kneads and blends powder materials.
Chopper blade: breaks wet mass into uniform granules.
Applications:
Wet granulation for tablets and capsules.
Improves granule uniformity and mechanical strength.
Advantages:
Easy control of mixing speed and processing time.
Suitable for both pharmaceuticals and nutraceuticals.
2. Fluid-Bed Dryer Granulator – 100 g
Drying capacity: approx. 100 g of wet granules.
Working principle:
Heated air flows upward, fluidizing the granule bed.
Moisture evaporates rapidly, resulting in uniform drying.
Equipped with a top-spray granulation system.
Features:
Adjustable temperature, airflow, and drying time.
Integrated dust collection filter.
Advantages:
Fast drying, uniform granulation.
No degradation of active ingredients.
✅ 2. Integrated System
The two units can be integrated to:
Transfer wet granules directly from the mixer to the fluid bed.
Reduce manual handling and avoid cross-contamination.
Easily evaluate formulation, processing time, and residual moisture.
🎯 3. Applications in R&D Laboratories
Used for:
Development of new pharmaceutical formulations.
Adjustment of excipients, solvents, and granulation parameters.
Process optimization prior to scale-up into large-scale production lines.
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Product information
Micro-Scale R&D Granulation system TCT-100g & FBDG-100g, manufactured by T&T MACHINERY, enables highly efficient laboratory-scale granulation, minimizes manual handling, and allows easy evaluation and optimization of the process before scaling up to industrial production.
Video: T&T MACHINERY Micro-Scale R&D Granulation system TCT-100g & FBDG-100g
🌟 Advantages of the Micro-Scale R&D Granulation system TCT-100g & FBDG-100g
1. Flexible integration – Supports diverse granulation needs
The system incorporates two core granulation technologies:
▸ High-Shear Granulation
▸ Fluid-Bed Granulation
This allows R&D teams to select the most suitable method based on formulation characteristics and research objectives.
T&T MACHINERY Micro-Scale R&D Granulation system TCT-100g & FBDG-100g
2. Reduced material consumption – Optimized trial costs
Both units feature small processing capacities (100 g), ideal for laboratory trials.
This significantly reduces raw material waste during early-stage formulation development, especially when working with high-value active ingredients.
3. Easy comparison & formulation optimization
With both granulation methods available in one integrated system, R&D teams can easily evaluate the impact of each process on:
▸ Granule size uniformity
▸ Residual moisture content
▸ Compressibility and API release profile
This shortens the time required to select the optimal formulation.
4. Less manual handling – Improved safety and cleanliness
The integrated design minimizes material transfers between process steps.
This helps reduce cross-contamination risks and limits direct operator exposure to raw materials.
5. Precise control – Reliable and reproducible results
The system uses modern control units that enable setup and recording of critical parameters such as impeller speed, atomizing pressure, temperature, drying time, etc.
This ensures reproducible results and facilitates smooth scale-up to commercial manufacturing.
6. Compact design – Ideal for laboratory environments
The equipment is compact, easy to install in R&D rooms, simple to operate, and easy to clean — compliant with GMP requirements for research environments.
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