Micro-Scale R&D Granulation system TCT-150g & FBDG-300g

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Micro-scale R&D Granulation System composed of a 150 g High-Shear Mixer integrated with a 300 g Fluid-Bed Granulator Dryer, manufactured by T&T MACHINERY, is a critical system for pharmaceutical formulation research and process optimization before scaling up to industrial production lines.

🔧 1. System Structure — Micro-Scale R&D Granulation system TCT-150g & FBDG-300g

1. High-Shear Mixer Granulator – 150 g

Working capacity: approx. 150 g — ideal for formulation studies and new product trials.

Main components:
- Main impeller: blends and kneads powder materials.
- Chopper blade: breaks wet mass into uniform granules.
Applications:
- Wet granulation for tablets or capsules.
- Enhances granule uniformity and mechanical strength.
Advantages:
- Easy control of mixing speed and processing time.
- Suitable for both pharmaceutical and nutraceutical formulations.
2. Fluid-Bed Dryer Granulator – 300 g

Drying capacity: approx. 300 g of wet granules.

Working principle:
- Heated air flows upward, fluidizing the granule bed.
- Moisture evaporates rapidly, providing uniform drying.
- Top-spray granulation system available.
Features:
- Adjustable temperature, airflow, and drying time.
- Integrated dust filtration system.
Advantages:
- Fast drying, uniform granulation,
- No degradation of active ingredients.
✅ 2. Integrated System

The two machines are integrated to:
- Transfer wet granules directly from the mixer to the fluid bed.
- Reduce manual handling and avoid cross-contamination.
- Enable accurate evaluation of formulation, processing time, and residual moisture.
🎯 3. Applications in R&D Laboratories

Designed for:
- New pharmaceutical formulation development.
- Adjustment of excipients, solvents, and granulation parameters.
- Process optimization prior to scale-up into full-scale production lines.

Product information

Micro-Scale R&D Granulation system TCT-150g & FBDG-300g, manufactured by T&T MACHINERY, enables highly efficient laboratory-scale granulation, minimizes manual handling, and allows easy evaluation and adjustment of the process before scaling up to industrial production.

Video: T&T MACHINERY Micro-Scale R&D Granulation system TCT-150g & FBDG-300g

🌟 Advantages of the Micro-Scale R&D Granulation system TCT-150g & FBDG-300g

1. Flexible integration – Supports multiple granulation methods

The system integrates two key granulation technologies:

▸ High-Shear Granulation
▸ Fluid-Bed Granulation

This allows R&D teams to choose the most suitable method based on formulation characteristics and research objectives.

T&T MACHINERY Micro-Scale R&D Granulation system TCT-150g & FBDG-300g

2. Reduced material consumption – Optimized trial costs

Both units feature small processing capacities (150 g – 300 g), ideal for experimental trials.

This reduces raw material waste during formulation development, especially when working with high-value APIs.

3. Easy comparison & formulation optimization

With both granulation methods available in one system, R&D teams can easily compare the impact of each process on:

▸ Granule size uniformity
▸ Residual moisture content
▸ Compressibility and API release profile

This significantly shortens the time required to select the optimal formulation.

4. Less manual handling – Improved safety and cleanliness

The integrated system minimizes material transfer between process steps.

This helps reduce cross-contamination risks and limits direct operator exposure to raw materials.

5. Precise control – Reliable and reproducible results

The system uses modern control units that allow configuration and recording of key parameters such as:

impeller speed
atomizing pressure
temperature
drying time, etc.

This ensures reproducible results and smooth scale-up to commercial manufacturing.

6. Compact design – Perfect for laboratory environments

The equipment is compact, easy to install in R&D rooms, simple to operate, and easy to clean — fully compatible with GMP requirements for research environments.

🔍Learn more: What is GMP? What are the benefits of GMP compliance?

7. Ready for scale-up

The technology accurately simulates the operating mechanism of industrial-scale systems.

Data generated on the R&D system helps minimize risk and reduce time during technology transfer to full-scale production.

Key customers using T&T MACHINERY Micro-Scale R&D Granulation system TCT-150g & FBDG-300g

VISTAFA JSC
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Technical specifications of Micro-Scale R&D Granulation system TCT-150g & FBDG-300g

1-High-shear mixer granulator

2-Fluid bed dryer granulator

Model: TCT-150 g

Granulation Mixing Capacity

Maximum batch size: 150 g/batch
Main impeller motor: 90 W — max speed 300 rpm
Chopper motor: 40 W — max speed 1,400 rpm
Power supply: 380 V, 3-phase, 50 Hz

Main Components & Configuration

7-inch color touch screen (Mitsubishi – Japan)
Mitsubishi PLC for automatic control
Mixing bowl material: SUS 316L stainless steel
Pneumatic discharge system
Designed in compliance with ISO & GMP standards

Documentation & Certification

User manual
IQ, OQ, FAT, DQ validation documents
Certificate of Stainless Steel (SUS 316L)

Model: FBDG-300 g

Control System

7-inch color touch screen (shared with the High-Shear Mixer)

Capacity

Drying capacity: 150 – 300 g/batch
Granulation capacity: 150 – 300 g/batch

Utility Requirements

Power supply: 380 V, 3-phase, 50 Hz

Construction Materials

Full stainless steel construction: SUS 304 & SUS 316L

Technical Specifications

Exhaust fan: 0.75 kW
Heater: 3 kW

Top-Spray Granulation System

Spray gun: 1 unit – Schlick (Germany)
Peristaltic pump: 1 unit – Watson-Marlow (UK)

Certificates & Documentation

CO & CQ
Electrical and pneumatic system included

ASSOCIATED EQUIPMENT

Micro-Scale R&D Granulation system TCT-150g & FBDG-300g | Integrated a high-shear mixer and a fluid-bed dryer system