Production of Herbal Capsules for Insomnia Treatment from Mimosa pudica, Erythrina variegata, Magnolia officinalis (Southern variety), and Glycyrrhiza uralensis (Southern licorice)

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Production of Herbal Capsules for Insomnia Treatment
Production of Herbal Capsules for Insomnia Treatment
Date Submitted: 08/12/2024

    On November 22, within the framework of the 2024 Technology Exchange, the Center for Science and Technology Information and Statistics (CESTI), in collaboration with the University of Medicine and Pharmacy in Ho Chi Minh City, organized a technology cooperation event themed “Production of Herbal Capsules for Insomnia Treatment from Mimosa pudica, Erythrina variegata, Magnolia officinalis (Southern variety), and Glycyrrhiza uralensis (Southern licorice)”, with the participation of representatives from T&T Pharmaceutical Machinery Co., Ltd. as the technology consulting partner.

    Research on formulation and evaluation of the sedative effect of Production of Herbal Capsules for Insomnia Treatment using Mimosa pudica, Erythrina variegata, Magnolia officinalis (Southern variety), and Glycyrrhiza uralensis (Southern licorice).

    Production of Herbal Capsules for Insomnia Treatment
    Sample of herbal capsules for insomnia treatment from Mimosa pudica, Erythrina variegata, Magnolia officinalis (Southern variety), and Glycyrrhiza uralensis (Southern licorice)

    Vietnam possesses a vast resource of medicinal plants that are widely used as raw materials for the production of health-care and wellness products. Among them, herbs such as Mimosa pudica (Xấu hổ), Erythrina variegata (Vông nem), Magnolia officinalis – Southern variety (Hậu phác nam), and Southern licorice (Cam thảo nam) are natural medicinal sources known for their safe, mild, and effective sedative and insomnia-relieving properties.

    These herbs have been applied in the study titled: “Production of hard capsules with sedative effects for insomnia treatment from Mimosa pudica, Erythrina variegata, Magnolia officinalis (Southern variety), and Southern licorice, opening new directions for product development and offering a more effective solution for managing insomnia symptoms.

    This research is the result of a scientific project led by the University of Medicine and Pharmacy in Ho Chi Minh City, which was officially accepted and approved by the Ho Chi Minh City Department of Science and Technology in 2024.

    Production of Herbal Capsules for Insomnia Treatment
    Dr. Hứa Hoàng Oanh (representing the research team from the University of Medicine and Pharmacy in Ho Chi Minh City) shared that the production process for the herbal-based insomnia-treatment capsules

    At the event, Dr. Hứa Hoàng Oanh (representing the research team from the University of Medicine and Pharmacy in Ho Chi Minh City) shared that the production process for the herbal-based insomnia-treatment capsules was developed from a traditional folk remedy that had been effectively applied in practice by Dr. Võ Đình Hưng. Through this study, the research team aims to further develop and enhance the efficacy of the remedy by optimizing the extraction process and conducting quality control to ensure maximum safety and therapeutic effectiveness.

     

    Research Content: Formulating Herbal Capsules for Insomnia Treatment

    Dr. Hứa Hoàng Oanh explained that insomnia can arise from various causes, and several studies have shown a strong correlation between symptoms of depression, anxiety, stress, and insomnia. Additionally, research indicates that approximately 19–74% of insomnia-related symptoms are associated with psychological factors. Besides psychological therapy, the use of sedative medication plays an important role in treating insomnia.

    In the domestic market, many sedative and anxiolytic products originate from synthetic pharmaceuticals. Although these medications are effective, their duration of use is limited, and they often cause unwanted side effects, including tolerance and dependence. Furthermore, most herbal-based products rely on imported ingredients, making quality control difficult and increasing production costs.

    The research team led by Dr. Hứa Hoàng Oanh aims to standardize the herbal extracts used in the traditional formula composed of Mimosa pudica (Xấu hổ), Erythrina variegata (Vông nem), Magnolia officinalis – Southern variety (Hậu phác nam), and Glycyrrhiza uralensis (Southern licorice) (Cam thảo nam). This is intended to ensure consistent quality during extract production, contributing to product safety and therapeutic efficacy. At the same time, the team sought to prepare hard capsules derived from the decocted herbal formula with sedative and insomnia-relief properties.

    According to Dr. Hứa, several studies have demonstrated the therapeutic effects of these herbs: Mimosa pudica helps reduce anxiety and depression and enhances memory; Southern licorice has sedative and anxiolytic properties; and Erythrina variegata exhibits anxiolytic and antidepressant effects.

    Chemical compounds found in the herbal materials, such as mimosine (present in Mimosa pudica) and coixol (a biologically active compound in Southern licorice), were used as marker substances for quality control of the formula.

    The herbal extract was preserved using potassium sorbate, added within permitted limits. Developing the formulation and production process for herbal insomnia-relief capsules addresses the needs of the Vietnamese pharmaceutical industry by gradually substituting expensive imported proprietary medicines and promoting domestic pharmaceutical development.

    In this study, the research team conducted five main tasks:

    1. Testing and evaluating raw herbal materials.

    2. Extracting herbal actives and establishing quality standards for the extracts.

    3. Investigating effective sedative and anxiolytic doses of the extracts.

    4. Formulating the capsule product.

    5. Assessing safety and evaluating sedative, anxiolytic, and antidepressant effects of the product on white mice subjected to isolation-induced stress.


    Research Results: Formulation of Herbal Sedative Capsules for Insomnia Treatment

    The results showed that the aqueous extract (freeze-dried to 0 percent moisture) exhibited no oral toxicity at a maximum dose of 18.16 g/kg body weight in experimental mice.

    Male and female white mice were administered the hard-capsule sedative formulation at doses equivalent to 1 capsule/kg to 2 capsules/kg, once daily for 60 consecutive days. The mice developed normally, showing no abnormalities in behavior, general condition, liver and kidney function, or hematological parameters. The product demonstrated sedative and antidepressant effects, was safe, and showed no signs of toxicity.


    Formula and Production Process for Herbal Sedative Capsules

    After evaluating suitable excipients and optimal ratios, the team successfully developed a hard-capsule formulation. Three laboratory-scale batches of hard capsules were produced, each containing 1,000 capsules.

    A pilot-scale manufacturing process was then established and tested on three research batches of 15,000 capsules each. The team also developed internal quality standards for the hard capsules in accordance with the guidelines of the Vietnamese Pharmacopoeia V, and conducted stability studies under real-time storage conditions as well as accelerated aging conditions.

    Dr. Hứa Hoàng Oanh stated that the outcomes of this project will serve as valuable scientific and practical reference materials for research and manufacturing units. The findings also provide a foundation for upgrading the standards and quality of domestic herbal extracts and herbal-derived products.

    Furthermore, the successful formulation of capsules and the evaluation of their sedative effects from the herbal insomnia-treatment decoction containing Mimosa pudica, Erythrina variegata, Magnolia officinalis (Southern variety), and Glycyrrhiza uralensis (Southern licorice) in Vietnam can help replace imported products, reduce production costs, enhance treatment effectiveness, and offer greater convenience for users.

     

    Opportunities for Technology Cooperation and Transfer in Producing Herbal Capsules for Insomnia Treatment from Mimosa pudica, Erythrina variegata, Magnolia officinalis (Southern variety), and Glycyrrhiza uralensis (Southern licorice)

    Production of Herbal Capsules for Insomnia Treatment
    Discussion on collaboration needs and technology transfer for formulating herbal insomnia-treatment capsules from Mimosa pudica, Erythrina variegata, Magnolia officinalis (Southern variety), and Southern licorice

    At the event, interested organizations shared valuable insights regarding opportunities for cooperation and the practical implementation of technology transfer in producing herbal insomnia-relief capsules. The discussions focused on key issues such as potential side effects, drug-dependence risks, product registration procedures, clinical trials, and production costs.

    Production of Herbal Capsules for Insomnia Treatment
    Mr. Nguyễn Hải Truyền (Director of T&T Pharmaceutical Machinery Co., Ltd.) sharing about T&T’s recirculating vacuum herbal extraction and concentration technology

    Mr. Nguyễn Hải Truyền, Director of T&T Pharmaceutical Machinery Co., Ltd. (T&T MACHINERY), stated that the company is ready to collaborate with the research team to develop the study’s outcomes into marketable products. T&T MACHINERY provides comprehensive technological solutions to optimize the production process of herbal capsules, helping shorten manufacturing time, reduce costs, and increase profitability for enterprises.

    At present, T&T Pharmaceutical Machinery Co., Ltd. has fully mastered the recirculating vacuum herbal extraction and concentration technology, which can be applied to the production of insomnia-relief capsules derived from Mimosa pudica, Erythrina variegata, Magnolia officinalis (Southern variety), and Glycyrrhiza uralensis (Southern licorice).

    The herbal extraction and concentration technology of T&T Pharmaceutical Machinery Co., Ltd. (T&T MACHINERY) operates at low temperatures, helping preserve the active compounds in medicinal plants. This ensures that the final extract retains its valuable therapeutic properties, enhances health benefits for consumers, optimizes extraction efficiency, reduces operating costs, and delivers strong investment value for enterprises.

    In addition, T&T MACHINERY provides complete traditional medicine production lines, from formulation to finished-product packaging, including liquid extracts, powders/granules, and hard capsules. These solutions fully meet the production needs of traditional medicine factories.

     

    Some featured products in the Traditional medicine production line manufactured by T&T MACHINERY

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    Fluid Bed Dryer Granulator for Herbal Medicine FBDG-200

    Video: T&T MACHINERY Fluid Bed Dryer Granulator for Herbal Medicine FBDG-200

    Introduction – Herbal Remedies Fluid Bed Dryer Granulator

    The Fluid Bed Dryer Granulator for Herbal Remedies is an essential piece of equipment in traditional medicine production as well as in the pharmaceutical industry in general.

    Applications in Herbal Medicine

    • Granulating dry extracts or herbal powders for tablet compression or instant tea production.

    • Rapidly drying extracted materials, saving time and improving efficiency.

    • Ensuring uniformity, reducing dust, and enhancing solubility of the final product.

    • Enabling granulation with minimal binders, suitable for the characteristics of traditional herbal ingredients.

    Video: T&T MACHINERY Herbal fluid bed dryer granulator FBDG-100

    Main Components

    1. Drying Chamber

    The core area where fluidization takes place.
    Made of stainless steel with high heat resistance and corrosion protection.
    Includes sieves or perforated plates that hold the materials while allowing hot air to pass through.

    2. Blower System

    Generates high-pressure airflow to move the material and create the fluidized state.
    Equipped with air filters to ensure clean air enters the chamber.

    3. Heater

    Usually electric or gas-heated, supplying thermal energy to the incoming air before it enters the drying chamber.

    4. Spray System

    Used to spray binder solutions or other liquids onto the material to aid granulation.
    May feature top-spray or bottom-spray designs depending on the machine configuration.

    5. Exhaust Air Filter

    Removes fine dust before releasing air into the environment, ensuring compliance with environmental standards.

    6. Control Panel

    Allows operators to run and monitor the drying process, adjusting parameters such as temperature, airflow, spray rate, and drying time.

    7. Product Discharge

    The outlet where the final dried or granulated material is collected.


    Working Principle

    • Fluidization

    When heated air is blown through a layer of material (powder or granules), it creates a “fluidized” state, causing the particles to move as if they were a flowing liquid.

    • Drying

    The hot air evaporates moisture inside the material, reducing the moisture content to the desired level.

    • Granulation

    A binder solution is sprayed during fluidization, causing powder particles to agglomerate into uniformly sized granules.

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    CX-200 Herbal extractor & concentrator system

    CX-200 Herbal extractor & concentrator system by T&T MACHINERY is manufactured with advanced Japanese technology, designed to save solvents, preserve active ingredients, and operate fully automatically according to GMP standards.

    Introduction to the Herbal Extractor and Concentrator System

    The Herbal Extractor and Concentrator System is specialized equipment used in the pharmaceutical, traditional medicine, and functional food industries. It extracts active ingredients from medicinal herbs and then concentrates the extract to obtain a solution with a high concentration of active compounds, saving solvents and improving production efficiency.

    Main Components

    • Extraction Tank: Heats the herbs with solvents (such as water, ethanol, methanol, etc.) to extract the active ingredients.

    • Condenser: Cools down the vaporized solvent and condenses it back into liquid form.

    • Solvent Recovery Tank: Collects the condensed solvent for reuse in the extraction process.

    • Concentrator: After extraction, the solution is transferred to the concentrator (usually a vacuum concentrator), which evaporates part of the solvent, thickening the extract without damaging heat-sensitive active ingredients.

    • Vacuum Pump: Lowers the pressure to reduce the boiling point, allowing extraction and concentration at lower temperatures, thus protecting sensitive compounds.

    • Automatic Control System: Monitors and adjusts temperature, pressure, and processing time.

    Working Principle

    • Extraction:
      The herbs are cooked in the solvent → active compounds dissolve into the solvent → forming the herbal extract solution.

    • Solvent Recovery:
      The solvent vapor is cooled down → condensed back into liquid → collected and circulated back to the extraction tank for reuse, saving solvent and reducing environmental impact.

    • Concentration:
      The extract solution is transferred to the concentrator → excess water or solvent is evaporated under reduced pressure → producing a concentrated extract with a high content of active ingredients.

    + More
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    Dry Herbal Extract Grinder

    🧾 Dry Herbal Extract Grinder – Introduction

    The Dry Herbal Extract Grinder is a vital piece of equipment in traditional herbal medicine (Eastern medicine) production. It is specifically designed to grind dry herbal extracts (concentrated extracts that have been dried) into fine powder, which is then used in the formulation of products such as pills, tablets, powders, granules, etc.


    ⚙️ Main Components

    A standard Dry Herbal Extract Grinder is composed of the following key parts:

    🔸 Feed Hopper

    • Where the dry extract material is loaded into the machine.

    • May be equipped with a regulating valve to control the feeding rate.

    🔸 Grinding Chamber

    • The core part containing the grinding mechanism, which may consist of:

      • Hammer blades (for hammer mills)

      • Rotating pins (for pin mills)

      • High-speed air jets (for jet mills)

    🔸 Filter Screen / Sieving Mesh

    • Installed inside the grinding chamber.

    • Functions to separate and allow only fine particles that meet size requirements to pass through.

    🔸 Suction Fan or Dust Collector (if applicable)

    • Extracts the fine powder after grinding.

    • Helps collect the powder efficiently and reduces material loss.

    🔸 Electric Motor

    • Powers the grinding mechanism.

    • Often paired with a gearbox or inverter to control speed.

    🔸 Machine Frame and Safety Covers

    • Made of SUS 304 or SUS 316 stainless steel, rust-proof and GMP-compliant for pharmaceutical use.


    🔁 Working Principle

    The working principle varies depending on the type of grinder. Below are typical examples:

    Hammer Mill Principle:

    • Dry extract is loaded via the feed hopper.

    • Hammer blades rotate at high speed (several thousand to tens of thousands of RPM).

    • The hammers impact the material, breaking it into smaller fragments.

    • Continuous impact and friction further reduce the size.

    • Once the powder is smaller than the mesh holes, it passes through the screen and is discharged through the outlet.

    Ultra-fine Grinding (Pin Mill / Jet Mill):

    • Utilizes high-speed airflow or electrostatic impact to break down the material.

    • Generates minimal heat, ideal for preserving sensitive active ingredients.

    • Achieves extremely fine particle sizes (as small as 10–50 microns).

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    Blister Packing Machine CP-250

    Video: T&T MACHINERY Blister Packing Machine CP-250

    Introduction to the Blister Packing Machine

    The Blister Packing Machine manufactured by T&T MACHINERY is a specialized device used in the pharmaceutical, nutraceutical, and various other industries to package products into blisters. It automatically seals capsules, tablets, and film-coated tablets into individual blister pockets, ensuring cleanliness, accurate counting, and convenience for both usage and distribution.


    💡 Basic Operating Principle of the Blister Packing Machine

    • Film Feeding (PVC/PVDC/Aluminum): The roll film is fed into the machine.

    • Heating: The plastic film is heated to soften and formable condition.

    • Forming: The forming mold creates individual blister pockets.

    • Product Feeding: Tablets or capsules are automatically filled into each pocket.

    • Sealing: Aluminum foil or plastic film is sealed onto the blister surface.

    • Cutting: The machine automatically cuts the blister sheets to the desired size.


    📦 Benefits of Using a Blister Packing Machine

    • Ensures products are tightly sealed, preventing contamination, dust, and moisture.

    • Allows easy counting and distribution of products.

    • Enhances the professionalism and appearance of the packaging.

    • Suitable for large-scale GMP-compliant production lines.

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    Herbal washing machine RDL-200

    Herbal Washing Machine

    The herbal washing machine is a crucial device in traditional herbal medicine production lines. It ensures that the raw materials are clean and free from soil, impurities, microorganisms, etc., before entering subsequent stages such as cutting, drying, extraction, and more.


    Construction of the Herbal Washing Machine

    • Material: Typically made from 304 or 316 stainless steel, ensuring corrosion resistance and safety for food and pharmaceutical use.

    • Washing Tank: Features a drain outlet or is designed as a horizontal cylindrical tank.

    • High-Pressure Water Spraying System: Equipped with nozzles for high-pressure water jets, or air pipes to generate strong aeration.

    • Agitators or Conveyors: May include paddles or conveyor belts to evenly stir the herbs during the washing process.


    Working Principle

    • Raw materials (roots, stems, leaves, etc.) are fed into the machine.

    • Water, sometimes mixed with ozone or a mild disinfectant solution, is sprayed or aerated at high pressure to dislodge soil and contaminants.

    • Some machines include a filtration and water recirculation system, helping to save water and protect the environment.

    + More

    The Technology Transfer and Cooperation Event on “Production of Herbal Capsules for Insomnia Treatment from Mimosa pudica, Erythrina variegata, Magnolia officinalis (Southern variety), and Glycyrrhiza uralensis (Southern licorice) once again affirms Vietnam’s advantages in possessing valuable medicinal herbs with therapeutic and health-enhancing properties, as well as the country’s growing capacity in R&D and the application of advanced technology in traditional medicine production.

    Production of Herbal Capsules for Insomnia Treatment
    Cooperation and Technology Transfer in the Production of Herbal Capsules for Insomnia Treatment

    In collaboration with traditional medicine factories across the country, T&T Pharmaceutical Machinery Co., Ltd. (T&T MACHINERY) designs and manufactures complete production line systems, providing comprehensive solutions for the commercialization of scientific and technological research outcomes. The company applies research results from universities and research institutes into practical production, creating dual benefits — improving consumer health while generating economic value for investors.

    CONTACT US:

    T&T PHARMACEUTICAL MACHINERY CO. LTD. 

    Factory: 174-175 Dang Cong Binh St, Hoc Mon District, Hochiminh City, Vietnam. 

    Registered office: 82 Giai Phong St, Tan Binh District, Hochiminh City, Vietnam. 

    Hotline Zalo: 0903.845.108 / 039.88888.39 / 0909.877.646

    Email: tivati7@gmail.com

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